| abstract |
The present invention relates to an improved approach for the treatment of microbial infections in mammals. Specifically, the invention provides method s and reagents of expressing in mammalian cells, proteins having anti-microbia l activity. The invention provides both genes, which have been modified to all ow expression and preferably secretion of active protein in desired mammalian cells or tissues, and methods of introducing such modified genes into desire d mammalian cells and/or tissues. Most specifically, genes encoding anti- staphylococcal proteins are delivered to mammalian cells and/or tissues by methods of gene delivery, including gene therapy and the production of transgenic animals, for the treatment of mastitis a ruminant animals.</SDOAB > |