http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2475606-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f244c6155c2c1d73694b62b1c889927 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f009fff2f31da9529566f0ef0e9f3b8 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-42 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-42 |
filingDate | 2003-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_879809377bf13596166e9c478bdf5db2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c53ced1d4994c9a8933e47f7e5d1b93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dc1775651ed1e6889066dba22966d64 |
publicationDate | 2003-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2475606-A1 |
titleOfInvention | Reversible oxidation of protein tyrosine phosphatases |
abstract | The invention relates to a method of identifying any protein tyrosine phosphatase (PTP) that undergoes reversible modification of PTP active site invariant cysteine within a cell, such that the phosphatase is transiently protected from irreversible active site invariant cysteine-directed PTP inactivating agents. Methods related to regulation of PTPs by reactive oxyge n species (ROS) in a cellular environment are provided. Multiple PTPs are show n to be reversibly oxidized and inactivated following treatment of cells with HZOZ or with physiological stimuli that promote ROS formation, and inhibitio n of PTP function is shown to contribute to ROS~induced mitogenesis. Transient oxidation of the PTP catalytic site invariant cysteine is exploited in metho ds to identify which of multiple candidate PTPs are components of a given biological signal transduction pathway, without a requirement for first specifically purifying any particular candidate PTP. |
priorityDate | 2002-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1775.