| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f861d7dfdde7b233339d4838364a8e8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-175
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-175
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2003-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_442937e3a29a997719555ed89aadb9e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e29ec07b015c16957565ad476f0527c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb56e9a6753528f53ef20bcfd2eb4b25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d903727b566268c400efaff38b8c0754
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e24acf0cb45679a122989ea55a1eabd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29f5b725b5ae07731d1eadcfc8a8523f |
| publicationDate |
2003-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2475493-A1 |
| titleOfInvention |
Inclusion complexes of semicarbazones into cyclodetrins and uses thereof |
| abstract |
The present invention is characterized by the preparation of semicarbazone and/or thiosemicarbazone formulations with cyclodextrins and their derivativ es and products obtained by this process. The present invention is characterize d by obtaining inclusion compounds of semicarbazone and/or thiosemicarbazones with cyclodextrins and their derivatives, which were tested in experimental epilepsy models and allowed the reduction of the anticonvulsant dose from 100mg/kg. This means an improvement in the bioavailability of the compounds in biological systems. These results obtained in animal models make semicarbazones and/or thiosemicarbazones included in cyclodextrins and their derivatives new anticonvulsant candidates. The present invention is also characterized by the improved efficacy of semicarbazones and/or thiosemicarbazones included in cyclodextrins and their derivatives in comparison to free components. In addition the present invention is also characterized by the pain killer effect of semicarbazones and thiosemicarbazones. The present invention is also characterized by a lowerin g of the dose necessary for the pain killer effect of semicarbazones and thiosemicarbazones upon inclusion into cyclodextrins. |
| priorityDate |
2002-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |