| abstract |
The invention relates to compounds of formulae (I) or (IA), wherein R1 and R2 are independently from each other and signify lower alkoxy, lower alkenyloxy, benzyloxy, hydroxy, -OCH(CH3)OC(O)-lower alkyl or OCH2C(O)N(R3)(R4), with the proviso that only one of R1 or R2 may be hydroxy; R3 and R4 are independently from each other and signify hydrogen, lower alkyl, lower alkenyl or cycloalkyl; or R1 and R2 form together with the carbon atom, to which they are attached the linking group X, wherein X is -O(CH2)nCH=CH(CH2)n0- or -O(CH2)mO-; n is l, 2 or 3; and m is 4-8. as well as pharmaceutically acceptable salts of said compounds. Compounds of the present invention can be used for the treatment of diseases where Serum Amyloid P Component depletion has a beneficial effect, in particular in the treatment or prevention of all forms of central and systemic amyloidosis. |