| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_892676934740cff38da9b8a4abd0a561 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
2002-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_720ab8e40e5c1a3cd7c4754746a5ce41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae5315591f67cbf1b43940aff6f2340
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95933883a39b558f6f0c986c773f7e55 |
| publicationDate |
2003-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2468479-A1 |
| titleOfInvention |
Podophyllotoxins as antiproliferative agents |
| abstract |
The invention relates to podophyllotoxins, uses thereof and methods of their production. In order to create hydrolytically activated prodrugs of etoposide VP-16 as inactive precursor molecules which are activated by hydrolysis, derivatives of the 4' phenolic hydroxy group were synthesised. The prodrugs of the present invention are stable under a wide range of pH values, yet can be activated by an appropriate change of pH, as well as under physiological conditions in the presence of naturally occurring enzymes. The prodrugs of the present invention reduce adverse reactions when administered to a patient and are capable of overcoming multidrug resistance commonly encountered with the parent molecule. |
| priorityDate |
2001-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |