| abstract |
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitor s of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasma level of free fatty acids, glycerol, LDL-cholesterol, HDL-cholesterol, insulin and/or glucose; and or modulate intracellular triacylglycerol and cholesterol stores, intracellular level of fatty acids, fatty acid esters such as diacylglycerols, phosphatidi c acids, long chain acyl-CoA's as well as citrate or malonyl-CoA; and or increase insulin sensitivity ; and or modulate insulin secretion from pancreatic beta cells. More particularly said disorders are selected from th e group consisting of insulin resistance, diabetes type 1, diabetes type 2, metabolic syndrome X, impaired glucose tolerance, hyperclycemia, dislipidemi a, obesity, abnormalities of lipoprotein metabolism and any combinations. there of. |