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filingDate 2002-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2011-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2468038-C
titleOfInvention Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
abstract The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I): in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.
priorityDate 2001-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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