| abstract |
The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the formula (I): wherein the hatched segment represents an .alpha. bonds, the solid triangle represents a .beta. bond, the wavy segments represent .alpha. or .beta. bond, dashed lines represent a double bond or a single bond, X is selected from the group consisting of hydrogen and halogen radicals, R3 is heteroaryl or a substituted heteroaryl radical, R1 and R2 are independently selected from the group consisting of hydrogen or a lower alkyl radical havi ng up to six carbon atoms, or a lower acyl radical having up to six carbon atom s, R is selected from the group consisting of CO2R4, CONR42, CH2OR4, CONR4SO2R4 , P(O)(OR4) and formula (II), wherein R4 is selected from the group consisting of H, phenyl and lower alkyl having from one to six carbon atoms and n is 0 or an integer of from 1 to 4. |