| abstract |
Recombinant adenovirus and methods of administration to a host are provided for eliciting immune response of the host to human immunodeficiency virus (HIV). The recombinant adenovirus is capable of expressing multiple wild type or mutant HIV antigens such as HIV envelope proteins without the cleavage site or the cytosolic domain, structural proteins such as Gag and its proteolytical fragments in a natural, secreted or membrane-bound form, HIV enzymes such as reverse transcriptase, protease and integrase, and regulatory proteins such as Tat, Rev and Nef. Immuno-stimulators such as cytokines can also be expressed by the recombinant adenovirus to further enhance the immunogenicity of the HIV antigens. |