| abstract |
The invention provides novel substituted 3-pyridyl indoles and indazoles and pharmaceutical compositions thereof. The invention also provides methods of use of substituted 3-pyridyl indoles and indazoles and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17.alpha.-hydroxylas e- C17,20-lyase enzyme. The invention further provides methods for the treatmen t of cancer in a subject, comprising administering a substituted 3-pyridyl indoles and indazoles or a pharmaceutical composition comprising a substitut ed 3-pyridyl indoles and indazoles to a subject. The cancer can be, e.g., prostate cancer or breast cancer. |