| abstract |
The present invention relates compounds of the formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8 and R10 repre sent a variety of substituents; A represents NR9 or O; B represents a bond, CH2, NR9 or O, wherein one or both hydrogen atoms in said CH2 moiety may be replaced with one or both of R7 and R8, or alternatively, one of the hydrogen atoms in said CH2 moiety together with a hydrogen atom from an adjacent carbon are replaced by a double bond; with the proviso that when A is O, then B is NR9; n is zero, 1 or 2; and pharmaceutically acceptable salts thereof. The compounds are of particular u se in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia. |