http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2458889-A1

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filingDate 2002-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3658f734030b7c3a0d1dbdea8e4575dd
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publicationDate 2003-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2458889-A1
titleOfInvention A process for preparing crystalline drug particles by means of precipitation
abstract A process for preparing crystalline particles of a drug substance is disclosed, said process comprising recirculating an anti-solvent through a mixing zone, dissolving the drug substance in a solvent to form a solution, adding the solution to the mixing zone to form a article slurry in the anti-solvent, and recirculating at least a portion of the particle slurry back through the mixing zone. Particles produced from the process are also disclosed. The present invention has the ability to be operated in a continuous fashion, resulting in a more efficient process and a more uniform product. The present invention has the additional advantage of having the ability to operate at a relatively low solvent ratio, thereby increasing the drug to excipient ratio.
priorityDate 2001-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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