http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2458600-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1010e3862914acdd087e73d76911ec6d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 |
| filingDate | 2002-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cccab31c8f2fc98eae189f09f02ebbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0465f3f4b20d1764f932ecfcea0dcb9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71b55d1854ed382ee4aec0d43cd52f7e |
| publicationDate | 2003-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2458600-A1 |
| titleOfInvention | Intermediates for synthesis of vinblastines, process for preparation of the intermediates and process for synthesis of vinblastines |
| abstract | Intermediates represented by the general formula (I) and being useful in the synthesis of vinblastines: [wherein R1, R2, R3, and R4 are each independently H, lower alkyl, lower alkoxy, halogeno, lower perfluoroalkyl, lower alkylthio, hydroxyl, amino, mono- or di-(alkyl or acyl)amino, or lower alkyl- or aryl-sulfonyloxy; R5 is H, lower alkyl, or substituted or unsubstituted aryl; R6 is alkyl having not more than four carbon atoms; R7 is substituted or unsubstituted aryl; R8 is substituted or unsubstituted aryl or lower alkyl; and R9 is acyl or trialkylsilyl]. A process for preparation of the above intermediates which comprises the synthesis of indole by radical cyclization of a thioanilide and the formation of a 11-membered cycle by intramolecular alkylation of 2-nitrobenzenesulfonamide and by which the reactions can proceed under mild conditions and high yield can be attained. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8895543-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7842802-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7238704-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7235564-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8053428-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7745619-B2 |
| priorityDate | 2001-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.