| abstract |
The present invention relates to the field of biology, genetics and of medicine. It relates in particular to new methods for detection, characterization and / or treatment (or management) of neurodegenerative pathologies, in particular of lateral sclerosis amyotrophic. The invention also relates to methods for the identification or screening of active compounds in these pathologies. The invention also relates to the compounds, genes, cells, plasmids or compositions useful for the implementation of the above methods. The invention describes in particular the role of PDE4B in these pathologies and its use as a therapeutic, diagnostic or experimental target. |