http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2456595-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2004-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ec17136b3189a08da8a6a4e955c8491 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad232888a846efd39176200b71294811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8944f9b90fa53b8a3f33072b672e6410 |
| publicationDate | 2005-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2456595-A1 |
| titleOfInvention | Process for identifying eukariotic tumor cells or bacteria arboring a genomic alteration in at least one part of a gene encoding for a transcription factor |
| abstract | Background: Phylogenetic analysis of the Archaea has been mainly established by IOS rRNA sequence comparison. With the accumulation of completely sequenced genomes, it is now possible to test alternative approaches by using large sequence datasets. We analyzed archaent phylogeny using two concatenated datasets consisting of 14 proteins involved in transcription and 53 ribosomal proteins (3.275 and 6.377) positions respectively). Results: Important relationships were confirmed, notably the dichotomy of the archaeal domain as represented by the Crenarchaeotic and Fluryarchaeoa, the sister grouping of Sulfolobales and Aeropyrum pernix, and the monophyly of a large group comprising Thermophanatales, Archaeoglus fulgidus. Methanosacrinable Halobacteriales, with the latter two orders forming a robust cluster. The main difference concerned the position of Methanopyrus kanderli, which grouped with Methanoceles and Methanobacteriales in the translation tree, whereas it emerged at the base of the euryetharates in the transcription tree. The incongruent placement of M. kandleri is likely to be the results of a reconstruction artifact due to the high evolutionary rates displayed by the components of its transcription apparatus. Conclusions: We show that two informational systems transcription and translation, provide a largely congruent signal for archaenl phylogeny, in particular, our analyses support the appearance of methanogenesis after the divergence of the Thermocolales and a late emergence of aerobic respiration from within methanogenic ancestors. We discuss the possible link between the evolutionary acceleration of the transcription machiery in M. kandleri and several unique features of this archaeon, in particular the absence of the elongation transcription factor TPS.~ |
| priorityDate | 2004-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.