http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2450661-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49a6b9e3e97489fe6c74ff0c2794d1f7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-0076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 2002-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_375d73bcedc3e5ed9d0c78056f9733af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42127054b76e4e6ca8b89e9413490682 |
| publicationDate | 2002-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2450661-A1 |
| titleOfInvention | Preparation of flumethasone and its 17-carboxyl androsten analogue |
| abstract | Process for preparing flumethasone (6.alpha.,9.alpha.-difluoro-11(3,17.alpha.,21-trihydroxy-16.alpha.-methyl-pregna-1,4-diene-3,20-dione), flumethasone 21-acetate or its 17-carboxyl androsten analogue of the formula: which process comprises (a) reacting a compound of formula (II) with benzoyl chloride to form a 3-enolic ester of the formula (IIIa): b) reacting the enol benzoate (IIIa) with an electrophilic fluorination agent to introduce fluorine in the C6- position to form a compound of formula (IIIb): (c) deprotecting the compound (IIIb) at C3 to form a compound of formula (IV): (d) fluorinating the 9,11-epoxy group of compound IV by reacting it with hydrofluoric acid to yield flumethasone 21-acetate; and optionally (e) hydrolysing the flumethasone 21-acetate, in the presence or absence of an oxidising agent, to yield compound (I) or flumethasone, respectively. |
| priorityDate | 2001-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.