http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2450501-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43b6da0b7e905dfc60e7126e7c0db997 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C39-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B57-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-86 |
| filingDate | 1997-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38c5788e1425feb40d180dbfac6adc30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f8a60a6fe84f30af6456365cac117c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38159a11f74981e63f574d17431dfe75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6608d61625fe7e6985b6b335787d987 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4836106b6e166ccc7df6dcad2f557264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cbcf49ca938506b2f6a9df7819c243a |
| publicationDate | 1997-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2450501-A1 |
| titleOfInvention | Asymmetric benzoxanthene dyes |
| abstract | A class of asymetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having structure (I) wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1-R8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having general structure (II) where substituents R3-R7 correspond to like-referenced substituents in the structure of described above, Y2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric bezoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods. |
| priorityDate | 1996-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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