http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2448795-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c07fc85adfac6f5bfe35e4839e490b4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2002-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0c9974124a13fe24aa95ec160437668 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6325db824e04f10e95626a1deab4225b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb5dfb49e9f0bd7ad397776cbe62431c |
| publicationDate | 2002-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2448795-A1 |
| titleOfInvention | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agent |
| abstract | Compounds which are prodrugs of triptolide or its derivatives, containing an amino acid or oligopeptide moiety, are used for anticancer or immunosupressi ve treatment. The compounds are of the structure (I) where X1 is OH or OR1, and X2 and X3 are independently OH, OR1 or H, with the proviso that at least one of X1, X2, and X3 is OR1, and at least one of X2 and X3 is H; and R1 is selected from the group consisting of: (a), (b): C(=O)CHY-NHP1, (c): C(=O)CH(NHP1)-(CH2)m-C(=O)OP2, (d): C(=O)(CH2)n-CH(NHP1)-C(=O)OP2 and (e): [C(=O)CHY-NH]Z-C(=O)CHY-NHP1; where Y is a side chain of a naturally occurri ng amino acid or a one- or two-carbon homolog thereof; P1 is selected from the group consisting of H, C(=O)OR2, and C(=O)R3, where each of R2 and R3 is independently H, alkyl, alkenyl, aryl or aralkyl; m is an integer from 0-5; n is an integer from 0-5; z is an integer from 2-10; and P2 is selected from t he group consisting of H, alkyl, alkenyl, aryl or aralkyl. |
| priorityDate | 2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.