http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2446039-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fde1000b69a309f08eb29a0aae0c4cd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-28 |
| filingDate | 2002-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc9b8d62a9811f37ce1d9fb45b59cf10 |
| publicationDate | 2002-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2446039-A1 |
| titleOfInvention | An assay for detecting inhibitors of the enzyme mueloperokidase |
| abstract | An assay for detecting inhibitors of the enzyme myeloperoxidase said method comprising: reacting myeloperoxidase with hydrogen peroxide and a chloride source to generate hypochlorus acid in the presence of a potential inhibitor of said myeloperoxidase; reacting any formed hypochlorous acid with a suitab le amine to form the corresponding chloramine; Optionally removing any unreacte d hydrogen peroxide; reacting any formed chloramine with a suitable detector molecule in the presence of iodide to form oxidised detector molecule; determining the amount of formed oxidised detector molecule by measuring the absorbance or fluorescence at a suitable wavelength; Identifying as inhibito rs of myeloperoxidase those compounds which cause the amount of formed oxidised detector molecule to be decreased. And for use in diagnostic tests for myeloperoxidase activity is disclosed. |
| priorityDate | 2001-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 638.