abstract |
The ABCA1 mRNA expression-promoting agent, LXR.alpha. mRNA expression-promoting agent, ABCG1 mRNA expression-promoting agent, cholesterol efflux-promoting agent, cholesteryl ester accumulation-inhibiting agent, ACAT-1 mRNA expression-inhibiting agent and CEH mRNA expression-promoting agent of the present invention are excellent in the ability to control cholesterol distribution in the body and have low toxicity. The ABC expression promoting agent pioglitazone, or a salt thereof, is used for the treatment of arteriosclerosis obliterans. |