| abstract |
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers (9102a, 9102b) of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers (9102a, 9102b), thereby simultaneously providing a large number of crystallization environments. Control over chang ed solution conditions may result from a variety of techniques, including but n ot limited to metering volumes of crystallizing agent into the chamber by volum e exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection o f sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels. |