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filingDate 2001-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c49ade9325a6d9fa54ceb5be8ada3b6
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publicationDate 2011-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2442582-C
titleOfInvention Bioactive surface layer, particularly for medical implants and prostheses
abstract A bioactive surface layer is provided, which may be used in a medical implant or a prosthesis. The bioactive surface layer is preferably applied to a valve metal or alloy thereof, or a barrier-forming metal coating. A bioactive surface layer comprising, a metal oxide portion in an amount of 25 to 95 atomic percent of a metallic base material and a variable proportion consisting of calcium phosphate phases, wherein the layer is porous, has a thickness of between 0.1 and 50.0 µm and further comprises amorphous or nanocrystalline calcium phosphates having a Ca/P ratio in a range of between 0.5 and 2.0 over the surface layer; wherein the Ca-ions and PO4-ions are embedded in the surface layer and distributed over the metal oxide portion; a pore density on the surface layer is between 10 4 and 10 8 pores/mm2; and the amorphous or nanocrystalline calcium phosphates are provided in an amount of 1 to 40 volume % of the total surface layer.
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