http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2439713-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc1cbf81635c47973bce6d4dfa73b5de http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21fd22463c3efbe2d9685874c48a3c8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76e43325a56e2457917dbf180a1cfcfa http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0eb4c13644e2b5daa4757f15e9a142d4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 |
| filingDate | 2002-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd7fbf3d63bac0b142277e091b990d3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e68d6d93bb094b2ef78c66f385f788f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2f53af37edde6eb45849abcf8389f83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55d39b3ac6c02eb0755945d4f6b10c52 |
| publicationDate | 2002-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2439713-A1 |
| titleOfInvention | Quantitative detection of the conformation changes of p-glycoprotein |
| abstract | The invention relates to the detection of the presence and/or conformation change of the cell surface receptors, pumps or proteins, when two different antibodies and optionally ligands are bound to the receptors, pumps and/or proteins recognized by the antibodies, and the change in the antibody-bindin g is measured. The method can be used for the determination of cytostatic drug combination, effective in case of multidrug resistance wherein the native cells are combined in vitro with the drug or drug combination to be tested, and the sample is tested with the method mentioned above. The method can be used for the detection of the efficiency of multidrug-resistance modulators wherein the method according is carried out in the presence of known modulat or or a modulator to be tested, and the resulting activity values are compared. Also the object of the invention is a diagnostic kit for the detection of th e presence and conformation change of receptors, pumps and proteins, for the determination of the efficient drug combination in case of multidrug resistance and/or for the detection of the efficiency of the modulators comprising a first antibody which is able to detect the receptors, pumps or proteins, optionally other ligands, and a system, which provides a system fo r the detection of binding. |
| priorityDate | 2001-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 210.