| abstract |
The invention features devices and methods for the delivery of a formulation to an individual to stabilize or increase bone mass by increasing bone deposition and/or decreasing bone resorption. In the present invention, a drug formulation comprising a bisphosphonate is provided parenterally in a sustained release dosage from, e.g., as an injected matrix or stored within a drug delivery device. In a specific embodiment, the dosage form may be implanted or injected into a site in the body (i.e., implantation site) and a conduit, e.g., a catheter, can be used to transport the formulation from the dosage form for release at a site in the body distal form the implantation site. |