| abstract |
This invention provides a method of preparing large liposomes with high entrapment capacity for pharmaceutical substances. The method generally entails infusing a lipid/alcohol solution directly into an aqueous polymer solution. The resulting liposome, which may be incorporated with a pharmaceutical substance, typically consists of multilamellar vesicles that have an average size of about 1 to 8 microns. The ratio of lipid to polymer, average molecular weight of the polymer, polymer concentration, ionic strength, and temperature of incubation are variables disclosed herein to control liposome size and incorporation of components and pharmaceutical substances. |