| abstract |
The invention relates to compounds of formula (I), wherein the variables have the following meanings: D means a phenyl or a pyridyl which is unsubstituted or is mono- or polysubstituted by Hal, A, OR2, N(R2)2, NO2, CN, COOR2 or CON(R2)2; R1 means H, Ar, Het, cycloalkyl or A, which can be substituted by OR2, SR2, N(R2)2, Ar, Het, cycloalkyl, CN, COOR2 or CON(R2)2; R2 means H or A, E means phenylene which can be mono- or polysubstituted by Hal, A, OR2, N(R2)2, NO2, CN, COOR2 or CON(R2)2 or piperidin-1,4-diyl, W means AR, Het or N(R2)2 and if E=piperidin-1,4-diyl, also R2 or cycloalkyl; and X means NH or O. These compounds are inhibitors of the coagulation factor Xa and can be used for the prevention and/or therapy of thromboembolic diseases and for treating tumours. |