| abstract |
The invention relates to HIV chimeric genes formed by the union of fragments of different genes of said virus, wherein said fragments contain epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary T cells, which are presented by a wide range of antigens of type 1 Major Human Histocompatibility System (HLA-1). Recombinant poxvirus are obtained from said genes, which are useful for prophylactic and therapeutic vaccination against HIV/AIDS infection, are capable of generating a protective immune cell response in vaccinated laboratory animals and are recognized by the CTL lymphocytes of HIV/AIDS patients. |