http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2430378-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_806f0a3a49d26f0b2efb79a3ea184ce9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1062 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate | 2001-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a243309ee10e6e026ed99442ebaf5c90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f36f18c5330c6662c15902964e59ac16 |
| publicationDate | 2002-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2430378-A1 |
| titleOfInvention | Substrate linked directed evolution (slide) |
| abstract | The invention relates to methods for the evolution of molecules with improved biological properties. In particular, the invention relates to methods using proteins that modify a DNA substrate to establish a link between the action of these proteins and the selection of molecules with improved biological properties. A unifying feature of all these mechanisms is that the coding region being evolved is in the same genetic element or on the same DNA molecule as a target site for a DNA-modifying protein. Accordingly, the activity (or inactivity) of the DNA-modifying protein can be tested by evaluating the sequence of its nucleic acid substrate. In this manner, a number of different types of compounds may be selected, including improved DNA- modifying proteins, improved substrates for DNA-modifying proteins, improved ligand-receptor interactions, improved co-factor and regulatory protein activities, improved DNA-binding proteins, and so on. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.