| abstract |
It is intended to provide carbapenem derivatives which have a potent antibacterial power on MRSA, PRSP, Haemophilus influenzaeand .beta.-lactamase- producing bacteria and a high stability to DHP-1. The above compounds involve compounds represented by the following general formulae (I) and (II) and pharmaceutically acceptable salts thereof, wherein R1 represents H or methyl; R2 and R3 represent each H, halogeno, optionally substituted alkyl, cycloalkyl, optionally substituted alkylcarbonyl, carbamoyl, optionally substituted aryl, optionally substituted alkylthio, morpholinyl, alkylsulfonyl or formyl; n is from 0 to 4; and Hy represents an optionally substituted, monocyclic or bicyclic heterocyclic group. |