http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2422366-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49310188df8dc04b3708491df863459f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8213 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 |
| filingDate | 2001-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c5c98de578ebd1b780f075b9831384b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8e72078d01ad20bf53960b34c8c8fd5 |
| publicationDate | 2002-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2422366-A1 |
| titleOfInvention | Targeted genetic manipulation using mu bacteriophage cleaved donor complex |
| abstract | Compositions and methods for targeted genetic manipulation of an organism ar e provided. The compositions are novel integration vectors derived from the Mu bacteriophage comprising an active cleaved donor complex (CDC) and further comprising a targeting mechanism whereby integration of the Mu transposable cassette may be directed to a predetermined target site within a host organism's genome. These integration vectors comprise a Mu transposable cassette and one or more navigator elements that direct targeted insertion o f the CDC. Methods of the invention utilize the integration vectors of the invention to insert the Mu transposable cassette into a target site of an organism's genome. The insertion occurs in the absence of the MuB accessory protein. The methods are useful for modulating activity of known genes and f or targeting integration of nucleotide sequences of interest into a specific location of an organism's genome. Accordingly, the methods may also be used to create gene disruptions and knockouts. |
| priorityDate | 2000-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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