| abstract |
The present invention provides chimeric reporter constructs, recombinant cel ls containing the reporter constructs, and assays utilizing the recombinant cel ls for detection of substances that interact with cell surface receptors, such as those of the G-protein coupled receptor family. The reporer constructs and recombinant cells are particularly well suited for high-throughput screening assays, and detection of interaction between a substance and a cell surface receptor can be performed visually, by FACS, or by luminometry. |