http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2419880-C

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filingDate 2001-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2010-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd23af4394eef4f8d55ff89746589615
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceb3f8a9b11b9f64694360f6aff5b205
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publicationDate 2010-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2419880-C
titleOfInvention 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1h)one derivatives
abstract The invention relates to pyrimidone derivative represented by formula (I) or a salt thereof wherein X represents hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, an ethenylene group, an ethynylene group, a 1,2-cyclopropylene, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxyde group, a carbonyl group, a nitrogen atom being optionally substituted; or a methylene group optionally substituted; R1 represent a 2,3 or 4-pyridyl group optionally substituted by a C3-6cycloalkyl group a C1-4alkyl group, a C1-4alkoxy group, a benzyl group or a halogen atom; when Y represents a bond , a methylene group optionally substituted or a carbonyl group then R2 represent a C1-16alkyl group, a C3-6cycloalkyl group, a C1-4alkylthio group, a C1-4alkoxy group, a C1-2perhalogenated alkyl group, a C 1-3halogenated alkyl group, a 5,6,7,8-tetrahydronaphthyl ring, a naphthyl ring, a phenylthio group, a benzyl group, a phenyl ring, a pyridyl ring, an indole ring, a pyrrole ring, a thiophene ring, a furan ring or an imidazole ring; when Y represents an ethenylene group, an ethynylene group, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxyde group or a nitrogen atom being optionally substituted then R2 represents a C1-6alkyl group, a C3-6cycloalkyl group, a C1-2perhalogenated alkyl group, a C1-3halogenated alkyl group, a naphthyl ring, a 5,6,7,8-tetrahydronaphthyl ring, a benzyl group, a phenyl ring, a pyridyl ring, an indole ring, a pyrrole ring, a thiophene ring, a furan ring or an imidazole ring. And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative diseases caused by abnormal activity of GSK3.beta. such as Alzheimer's disease.
priorityDate 2000-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8E5V5
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1WW18
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8CWX0
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0MH77
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A3Z1
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6TSC8
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID410399590
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5N1P1
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0M712
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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID397663
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Total number of triples: 866.