| abstract |
The invention provides new macrolides antibiotics of formula (I) with improv ed biological properties and improved stability formula (I): wherein R1 is hydrogen, cyano, -S(L)mR2, -S(O)(L)mR2, or -S(O)2(L)mR2; L represents -(CH2) n- or -(CH2)nZ(CH2)n'-; m is 0 or 1; n is 1, 2, 3, or 4; n' is 0, 1, 2, 3, or 4 ; Z is O, S or NH; R2 is hydrogen, alkyl, heterocyclyl or aryl; which heterocyclyl and the aryl groups may be further substituted; * indicates a chiral center which is in the (R) or (S) form and pharmaceutically acceptabl e acid addition salts or in vivo cleavable esters thereof. |