| abstract |
Provided are antibacterial compounds having Formula (I) wherein X is CH, O, S, N or NH; Y is CH or N; n is 0 or 1; one of R~1 and R~1' is -C(O)NR~5R~5', - C(O)-Q-NR~5R~5', -CH~2NR~5R~5' or -S(O)~2NR~5R~5' and the other is H or R~3, one of R~2 and R~2' is -NHC(O)R~6 or -NHS(O)~2R~6 or -NHS(O)R~6 and the othe r is H or R~4; Q is an amino acid or peptide; R~3 is H, halogen, -NR~5R~5' or - NHC(O)R~6; R~4 is selected from the group consisting of H, halogen, hydroxyl , amino, carboxyl, alkyl, alkenyl and alkynyl; R~5 is selected from the group consisting of H, alkyl, alkenyl or alkynyl optionally substituted with halogen, OH, amino, amidinyl, guanidinyl, urea, alkyl, carboxyl, oxo, carboxamide; R~5' is H or R~5 and R~5' together form a 5-16 member heterocyc le optionally substituted with halogen, OH, amino, alkyl, carboxyl, carbonyl or carboxamide; and R~6 is selected from the group consisting of H; amino, alky l, alkenyl or alkynyl, each optionally substituted with halogen, amino, amidiny l, guanidinyl, urea, carboxyl or carbvoxamide; a 5-16 member carbocycle or heterocycle; and a 5-16 member heterocycle-substituted alkyl or carbocycle- substituted alkyl, wherein said carbocycle and heterocycle are optionally substituted with halogen, OH, amino, alkyl, carboxyl, oxo or carboxamide.</S DOAB> |