| abstract |
The subject of the invention is new cdc25 phosphatase inhibitors, and particular of cdc25-C phosphatase, which correspond to the general formula (I) in which A represents an optionally carbocyclic aryl radical substituted 1 to 3 times with one or more radicals independently chosen from a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical in which R1 and R2 represent a hydrogen atom or an alkyl radical or R1 and R2 together with the nitrogen atom form a 4- to 7-membered heterocycle with 1 to 2 heteroatoms, the links necessary to complete the heterocycle being independently chosen from the radicals CR3R4-, -O-, -S-AND NR5-, R3 and R4 independently representing each time they intervene a hydrogen atom or an alkyl, hydroxy, alkoxy radical, amino, alkylamino or dialkylamino, and R5 independently representing each once a hydrogen atom or an alkyl radical occurs, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times with one or more radicals independently chosen from a halogen atom or an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical in which R1 and R2 represent a hydrogen atom or an alkyl radical; B represents a radical (CH2) q- or (CH2) j-CO- (CH2) n- or- (CH2) p-, I and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents an atom hydrogen or an alkyl radical; X represents a radical - (CH2) q- or - (CH2) j-CO- (CH2) r-, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl radical. Aminophenyl, alkylaminophenyl or dialkylaminophenyl or the radical (T) represented below. |