| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9351a1fd2f7ed6e980c0042e0726c2b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a178c79b4252f65d0e5a2c03ab64942d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-49 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate |
2001-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e594a7979ef31330970b6a76114c398c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34753c0e6c161a3b8f97c6ee302f84eb |
| publicationDate |
2002-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2416813-A1 |
| titleOfInvention |
Mutated pf-4, its fragments and mutated fusion peptides, their analogues, corresponding dna, cdna and mrna sequences and their use for inhibiting angiogenesis |
| abstract |
The subject of the invention is a peptide chosen from the group consisting of PF-4, the fragments and peptides of fusion derived from PF-4, and their analogs, exhibiting angiogenesis-inhibiting activity, in which glutamine in position 56 in the native PF-4 is replaced by an arginine, a lysine or a histidine, preferably an arginine. A peptide according to the invention has an I50 lower than the I50 of the same peptide having no mutation in 56. The subject of the invention is also the DNA or cDNA sequences coding for the peptides according to one of the invention, and the use of its sequences and / or of these peptides for the preparation of a medicament intended for inhibition of angiogenesis and / or cell proliferation. |
| priorityDate |
2000-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |