http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2415022-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 |
| filingDate | 2001-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_163c7d5c94cf3ca4fcc69468e2c0175b |
| publicationDate | 2002-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2415022-A1 |
| titleOfInvention | Cinnoline compounds |
| abstract | The invention relatest to compounds of the formula (I) wherein either any one of G¿1?, G¿2?, G¿3?, G¿4? and G¿5? is nitrogen and the other four are -CH-, or G¿1?, G¿2?, G¿3?, G¿4? and G¿5? are all -CH-; Z is -O-, -NH-, -S-, -CH¿2?- or a direct bond; Z is linked to any one of G¿1?, G¿2?, G¿3? and G¿4? which is a free carbon atom; n is an integer from 0 to 5; any of the substitutents R?1¿ may be attached at any free carbon atom of the indole, azaindole or indazole group; m is an integer from 0 to 3; R?a¿ represents hydrogen; R?b¿ represents hydrogen or another value as defined herien; R?1¿ represents hydrogen, oxo, hydroxy, halogeno, C¿1-4?alkyl, C¿1-4?alkoxy, C¿1-4?alkoxyC¿1-4?alkyl, aminoC¿1-4?alkyl, C¿1-3?alkylaminoC¿1-4?alkyl, di(C¿1-3?alkyl)aminoC¿1-4?alkyl, -C¿1-5?alkyl(ring B) wherein ring B is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-methylpiperazinly, N-ethylpiperazinyl, morpholino and thiomorpholino; R?2¿ represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C¿1-3?alkyl, C¿1-3?alkoxy, C¿1-3?aklylsulphanyl, -NR?3¿R?4¿ (wherein R?3¿ and R?4¿, which may be the same or different, each represents hydrogen or C¿1-3?alkyl), or R?5¿X?1¿-(wherein R?5¿ and X?1¿ are as defined herein) and salts thereof, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and the use of a compound of formula I in the manufacture of medicament for the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals.The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis. |
| priorityDate | 2000-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 433.