| abstract |
A compound of formula (I) wherein, independently at each occurence, v, w, an d x are selected from C, N, O, and S, with H substitition as needed to fulfill open valence sites; y and z are selected from N and C, with H substitution a s fulfill open valence sites, with the proviso that each of w, v, x, y and z i s not simultaneously C; the ring formed from v, w, x, y and z may be saturated or unsaturated; and R1, R2, R3 and R4 are selected from hydrogen, alkyl, ary l, alkaryl, aralkyl, heteroalkyl, and heteroaryl; wherein any adjacent two of R 1, R2, R3 and R4 may join together to form a 5, 6 or 7-membered carbocyclic or heterocyclic ring, with the proviso that each of R1, R2, R3, and R4 is not simultaneously hydrogen. Pharmaceutical compositions of said compounds, and methods of use in the treatment of biological conditions including cellular hyperproliferation, are disclosed. |