http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2412582-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfd617dc43a4c986d2dd81e4cb39d9dd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2001-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53897f0cfc01e9388d8ac20a28cfcb39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_222bb8e633a64feb11a9668a331581c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faf825689d130d1d7a709bf3a115e64e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8e77864b398babd1372047e1893f35d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05e22a779da4e7e1bc9b49f45304f917 |
| publicationDate | 2002-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2412582-A1 |
| titleOfInvention | Dds compound and process for the preparation thereof |
| abstract | A DDS compound which comprises (1S,9S)-1-amino-9-ethyl -5-fluoro-2,3-dihydro -9- hydroxy-4-methyl-1H,12H-benzo[de]- pyrano[3',4':6,7]indolizino[1,2-b]quinoli ne- 10,13(9H,15H)- dione as the drug compound and carboxymethyldextran polyalcoh ol and in which the 1-position amino group of the former is bonded to the carboxyl groups of the latter through a spacer consisting of either one amin o acid or 2 to 8 amino acids bonded by peptide linkages, characterized in that the amount of the drug compound residue introduced is 3.2 to 8.4 wt% and tha t the carboxymethyldextran polyalcohol has an average molecular weight of 240,000 to 480,000 and a degree of carboxymethylation of 0.14 to 0.47. A process for the preparation of the DDS compound which comprises the step of adding an aqueous solution of sodium periodate to an aqueous solution of dextran at a temperature of 4.ordm.C .plusmn. 2.ordm.C to oxidize the dextra n, and then adding the resulting reaction fluid to an aqueous solution of sodiu m borohydride at a temperature of 15.ordm.C or below to thereby obtain dextran polyalcohol. |
| priorityDate | 2000-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.