| abstract |
The invention relates to a method for identifying inhibitors or ligands for binding domains. The inventive method comprises using a protein that has at least one catalytic domain, incubating it with a marker substrate that binds to the catalytic domain of the protein and reacts therewith, with a substrate that can reversibly bind to the catalytic domain and to the binding domain, and with the inhibitor, and detecting whether the protein reacts with the marker substrate. |