| abstract |
The present invention relates to microspheres intended to be administered by injection comprising a protein active ingredient and a agent coating the active ingredient, intended to prolong its release, free of any trace of organic solvent, and likely to be obtained by a coating process involving contacting under stirring of the active ingredient and the coating agent in a fluid supercritical, said coating agent being soluble in the fluid supercritical. The protein active ingredient is not denatured. |