abstract |
Novel benzothiophene derivatives of the general formula (I) or salts thereof; and inhibitors against steroid 17a hydroxylase and/or C17-20 lyase, or pharmaceutical compositions, containing the derivatives or the salts (I), wherein Ar is a substituted or unsubstituted aromatic heterocyclic group; and R is amino which may be mono- or di-substituted with one or more members selected from among hydroxyl, lower alkyl, lower alkyloxy, halogeno, carboxyl, lower alkyloxycarbonyl, carbamoyl, amino, lower alkyl, and lower acyl ; cyano; optionally substituted phenyl; optionally substituted phenoxy; optionally substituted phenyl-lower alkyl; optionally substituted phenyl- lower alkyloxy; or an optionally substituted aromatic heterocyclic group. |