http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2409717-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18b3d4eb4d27c41a4a4a9e052d94c590 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea9726488bb8d52ab286d7325dccaeb5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2001-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67a51fb5035c3fb9f9282df346022484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb5f3f9d833108d8156ba82b6df4b27e |
| publicationDate | 2001-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2409717-A1 |
| titleOfInvention | Assay for cell cycle modulators |
| abstract | The present invention relates to the finding that cyclin D1 is targeted for destruction in cells which have been exposed to ionising radiation (IR). This finding gives rise to an assay for modulators of cell cycle control, which assay comprises: (a) providing a cell in culture together with apotential modulator compound, said cell expressing a cyclin D1 which undergoes degradation in response to DNAdamage; (b) exposing said cell to a DNA damaging agent; and (c) determining the extent to which the presence of the potential modulator compound inhibits the degradation of said cyclin D1.This finding further gives rise to an assay for modulators of cell cycle control, which assay comprises: (a) providing a cyclin D1, the APC or a componentthereof which interacts with cyclin D1, together with apotential modulator compound; and (b) determining the extent to which the presence of thepotential modulator compound inhibits the interaction ofsaid cyclin D1 and APC or component thereof. In particular where the component of the APC is a protein cdc20. |
| priorityDate | 2000-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 461.