| abstract |
0he invention generally relates to novel compositions and methods with an opioid agonist and an opioid antagonist to differentially dose a human subje ct so as to either enhance analgesic potency without attenuating an adverse sid e effect of the agonist, or alternatively maintain the analgesic potency of th e agonist while attenuating an adverse side effect of the agonist. The inventi on additionally relates to novel opioid compositions and methods for the gender - based dosing of men and women. |