| abstract |
The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods for their use. The compounds of the present invention are cyclic polyketides (also referred to as a "macrolides" or "macrolactones") that include Formula (I) as part of their structure and bind to a FK binding protein wherein R4 and R5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R4 and R5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs. |