http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2406391-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22853c8669cb52e7d6fea1eea6467958 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1093 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 1998-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45df741e39b510df9127eba764ac0fb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b688aa8626b0d7e484f93c58f47e2d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e815fb32c86e9b71d9d90a5c2f21ee0c |
| publicationDate | 2005-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2406391-C |
| titleOfInvention | Normalized nucleic acid libraries and methods of production thereof |
| abstract | The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules that are complementary to one or more of the nucleic acid molecules of the library, such that the variation in the abundances of the individual nucleic acid molecules in the library is reduced. The invention also relates to production of normalized nucleic acid libraries (particularly cDNA libraries) in which contaminating nucleic acid molecules have been reduced or eliminated, and to normalized nucleic acid libraries produced by such methods. |
| priorityDate | 1997-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 535.