http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2406384-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-16 |
| filingDate | 2001-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b42807fdbcd69e6f1c7738b2a465f0db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92847e22da948967a03104611e1bfd71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_704a653507b54f8d3df34334b886efac |
| publicationDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2406384-C |
| titleOfInvention | Synthesis of intermediates useful in preparing antihistamine tricyclic compounds |
| abstract | A process is provided for preparing a compound having the formula (I) comprising (a) reacting a compound having the formula (II) with an isocyanate having the formula R1NCO to produce a compound having the formula (III), (b) optionally hydrolyzing the compound of formula (III) to form an amide having the formula (IV), (c) reacting the compound of formula (III) or the amide of formula (IV) with a compound having the formula (V) in the presence of a strong base to produce a compound having the formula (VI), and (d) cyclizing the compound of formula (VI) to obtain the compound of formula (I), wherein R is H or Cl, M is selected from the group consisting of Li, Na, K, MgX, ZnR A, and Al(R A)2, R A is alkyl, X is halo, R1 is selected from the group consisting of alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, and heterocycloalkylalkyl, and L is a leaving group. Also provided is a process for preparing a compound having the formula (VIII) comprising reacting a compound having the formula (II) with CO2 and a protonating agent to obtain the compound of formula (VIII), wherein M is selected from the group consisting of Li, Na, K, MgX, ZnR A, and Al(R A)2, wherein R A is alkyl and X is halo. |
| priorityDate | 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.