| abstract |
A compound of the formula (see formula I) wherein, W is O, CH2, CF2, substituted amino, thio, sulfinyl or sulfonyl; R1, R2 and R3 are H, halo, cyano, trifluoromethyl, trifluoromethoxy or alkyl; R4 is H, halo, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, hydroxy, alkoxy, cycloalkoxy, heterocycloalkoxy, aryloxy, heteroaryloxy, substituted sulfamoyl, substituted carbamoyl, formyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, cycloalkylcarbonyl, cycloalkylalkylcarbonyl, aroyl, heteroaroyl, haloaroyl, substituted methoxy, substituted iso-carbamoyl, substituted aminocarbamoyl, substituted sulfoamino or substituted thio, sulfinyl or sulfonyl; R5 is hydroxy, fluoro, alkoxy or substituted carboxy; R6 is H, acetyl or alkyl; R7 is H or alkyl; R8 is hydroxy or alkoxy; and R13 is H, halo or alkyl, useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss. |