| abstract |
Disclosed is a formulation for delivery of a nucleic acid molecule to a cell, comprising a nucleic acid and an anionic polymer selected from the group consisting of poly glutamic acid, poly aspartic acid, a copolymer consisting of glutamic acid and aspartic acid, and salts thereof, wherein the anionic polymer is non-encapsulating and enhances delivery of the nucleic acid to the cell compared to delivery of the nucleic acid without the polymer, and wherein the formulation does not contain a, cationic polymer. Examples of the anionic polymer includes poly-amino acids such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid, and salts thereof. |