| abstract |
The invention relates to a compound of formula (1) wherein R1 is a sugar; R2 is -CH2-O-(R7)m, R7 representing a sugar, or R2 is -COOH; R3 is an epoxide-comprising group, C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4, R6, R8 and R10 independently of one another are H,C1-C6-alkyl, C1-C6-alkenyl, C1-C6-Alkynyl, -X2H, or -X2R12, or R4 and R6 together and/or R8 and R10 together are =X2; X2 is O, NH, N-C1-C6-alkyl, N-C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-Alkenyl, C2-C6-alkynyl, C1-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; and its physiologically acceptable salts. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for their preparation and to the use of the compounds as pharmaceuticals, for example as anti-tumor agents. |